Drug Delivery
Development of various drug-releasing hydrogel patches for the treatment of glioblastoma.
Delivering All-Trans Retinoic Acid to the Tumor Site
In this work, drug-releasing microparticles were fabricated and incorporated into 3D bioprinted hydrogel patches. These patches induced apoptosis in glioblastoma cells while maintaining the viability of human primary astrocytes. More information can be found here.
Delivering Temozolomide to the Tumor Site
In this project, a novel method was developed to load amphiphilic anti-tumour drugs like temozolomide into polymeric microparticles. 3D bioprinted meshes, laden with these microparticles, induced apoptosis in various glioblastoma cell lines. More information can be found here.
Publications
1- Mirani B, Pagan E, Shojaei S, Duchscherer J, Toyota B, Ghavami S, Akbari M. A 3D-bioprinted hydrogels mesh loaded with all-trans retinoic acid for treatment of glioblastoma. European Journal of Pharmacology. 2019 | 854, pp. 201-212, doi: 10.1016/J.EJPHAR.2019.04.007.
2- Hosseinzadeh H*, Mirani B*, Pagan E, Mirzaghaei S, Nasimian A, Kawalec P, Rosa S, Hamdi D, Fernandez N, Toyota B, Gordon J, Ghavami S, Akbari M. A drug-eluting 3D-printed mesh (GlioMesh) for management of glioblastoma. Advanced Therapeutics. 2019 | 2(11), pp. 1970023, doi: 10.1002/adtp.201970023. *Equal contribution. Front cover illustration.