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Development of various biofabrication methods for tissue engineering applications.


A Novel Method for 3D Bioprinting of Photo-Crosslinkable Polymers with Control Over Polymer Concentration and Final Hydrogel Porosity


Hydrogel structures with tunable porosity were generated using microfluidic bioprinting combined with computational modelling. In a coaxial flow system, the radial diffusion of photo-crosslinkable polymers, running in the core flow, was controlled by adjusting the viscosity of the sacrificial sheath flow to provide control over hydrogel porosity.  More information can be found here.


A New Method to Fabricate Fibres with Tunable Microarchitecture

Using 3D printing, various extruder systems were developed to produce meter-long solid and hollow fibres with tunable microarchitecture from a variety of biomaterials.

These fibres were used to fabricate more complex structures via weaving braiding, and embroidering methods. Click here for more information.

Publications in Biofabrication

1- Mirani B, Stefanek E, Godau B, Dabiri SMH, Akbari M. Microfluidic 3D printing of a photocrosslinkable bioink using insights from computational modeling. ACS Biomaterials Science and Engineering. 2021 | 7(7), pp. 3269-3280, doi: 10.1021/acsbiomaterials.1c00084.

1- Mirani B, Pagan E, Shojaei S, Dabiri SMH, Savoji H, Mehrali M, Sam M, Alsaif J, Bhiladvala R, Dolatshahi-Pirouz A, Radisic M, Akbari M. A facile method for fabrication of meter-long multifunctional hydrogel fibers with controllable biophysical and biochemical features. ACS Applied Materials & Interfaces. 2020 | 12(8), pp. 9080-9089, doi: 10.1021/acsami.9b23063.

2- Pedde RD*, Mirani B*, Navaei A, Styan T, Wong S, Mehrali M, Thakur A, Mohtaram NK, Bayati A, Dolatshahi-Pirouz A, Nikkhah M, Willerth SM, Akbari M. Emerging biofabrication strategies for engineering complex tissue constructs. Advanced Materials. 2016 | 29(19), p. 1606061. doi: 10.1002/adma.201606061. *Equal contribution.

13- Memic A, Navaei A, Mirani B, Cordova JAV, Aldhahri M, Dolatshahi-Pirouz A, Akbari M, Nikkhah M. Bioprinting technologies for disease modeling. Biotechnology Letters. 2017 | 39(9), pp. 1279–1290. doi: 10.1007/s10529-017-2360-z.

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