Cardiac and Muscle Tissue Engineering
Fibres with tunable microarchitecture regulated myoblasts and cardiomyocyte alignment. From left to right: randomly oriented myoblasts to highly aligned myotubes.
A Novel Method to Fabricate Grooved Fibres
Using 3D printing, various extruder systems were developed to produce Meter-long solid and hollow fibres with tunable microarchitecture from a variety of biomaterials.
Assembling Fibres into More Complex Structures
A variety of structures were fabricated via weaving braiding, and embroidering methods. These structures were designed to exhibit magnetic, electrical, and drug-releasing functionalities for tissue engineering, soft robotics, and therapeutic applications.
Biological Activity
The grooved fibres were shown to upregulate myogenic gene expression and induce the alignment of myoblasts, cardiomyocytes, and cardiac fibroblasts. More information can be found here.
Publications in Cardiac and Muscle Tissue Engineering
1- Mirani B, Pagan E, Shojaei S, Dabiri SMH, Savoji H, Mehrali M, Sam M, Alsaif J, Bhiladvala R, Dolatshahi-Pirouz A, Radisic M, Akbari M. A facile method for fabrication of meter-long multifunctional hydrogel fibers with controllable biophysical and biochemical features. ACS Applied Materials & Interfaces. 2020 | 12(8), pp. 9080-9089, doi: 10.1021/acsami.9b23063.
2- Siqueira NM, Chung S, Shrestha S, Zhong A, Caruso L, Mirani B, Mirzaei Z, Simmons CA, Santerre JP. Bioinspired oligo-urethane nanoparticles for delivering exogenous C-type natriuretic peptide: synthetic biomaterial nanocarrier complexes and their interactions with cardiac myofibroblasts. Biomacromolecules. 2023 | doi: 10.1021/acs.biomac.3c00210.